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Elevated urine albumin excretion linked to intra-abdominal fat in type 1 diabetes
Monday, 29 November 1999 19:00 | 
| Medicexchange News - Medicexchange News |
Elevated urine albumin excretion is more strongly associated with intra-abdominal fat (IAF) than with abdominal subcutaneous fat (SQF) in men with type 1 diabetes, suggest the results of a new study.
Elevated urine albumin excretion is more strongly associated with intra-abdominal fat (IAF) than with abdominal subcutaneous fat (SQF) in men with type 1 diabetes, suggest the results of a study published in the July issue of Diabetes Care.
"We previously examined obesity-related factors and albumin excretion within the total Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC) cohort," Dr. Shalamar D. Sibley, of the University of Minnesota, Minneapolis, and colleagues write. "In our cross-sectional analysis four years after the end of the DCCT, waist-to-hip ratio -- a visceral fat surrogate -- was associated with elevated albumin excretion."
In the current study, the researchers examined whether IAF relates more strongly to elevated albumin excretion than SQF. They assessed IAF and other obesity measures in relation to urine albumin excretion in a cohort of 64 clinical trial participants.
Trained technicians blinded to the status of the participants read single-slice umbilical abdominal computed tomography scans for IAF and SQF. Urine was collected from second-morning voids, and urinary creatinine and microalbumin were measured. The team defined elevated urine albumin-creatinine ratio (ACR) as at least 30 mg/g creatinine.
Of the 64 subjects, nine had elevated urine ACR. Six of those cases had microalbuminuria (ACR 30 to 300 mg/g) and three had clinical albuminuria. Men with elevated ACR were more likely than those with normal ACR to smoke, use ACE inhibitors, and to have received conventional insulin therapy during the clinical trial. Men with elevated ACR were also more likely to have higher blood pressures, higher levels of glycosylated hemoglobin, and dyslipidemia.
The researchers report that IAF, but not SQF, was greater in men with elevated ACR compared to those with normal ACR (p = 0.048). Waist circumference (p = 0.048) and waist-to-hip ratio (p = 0.006) were greater in men with elevated ACR.
There was an association between elevated ACR and greater levels of each obesity measure, except SQF.
"Futures studies are needed to elucidate mechanisms underlying the IAF-albumin excretion link," the authors conclude.
"We previously examined obesity-related factors and albumin excretion within the total Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC) cohort," Dr. Shalamar D. Sibley, of the University of Minnesota, Minneapolis, and colleagues write. "In our cross-sectional analysis four years after the end of the DCCT, waist-to-hip ratio -- a visceral fat surrogate -- was associated with elevated albumin excretion."
In the current study, the researchers examined whether IAF relates more strongly to elevated albumin excretion than SQF. They assessed IAF and other obesity measures in relation to urine albumin excretion in a cohort of 64 clinical trial participants.
Trained technicians blinded to the status of the participants read single-slice umbilical abdominal computed tomography scans for IAF and SQF. Urine was collected from second-morning voids, and urinary creatinine and microalbumin were measured. The team defined elevated urine albumin-creatinine ratio (ACR) as at least 30 mg/g creatinine.
Of the 64 subjects, nine had elevated urine ACR. Six of those cases had microalbuminuria (ACR 30 to 300 mg/g) and three had clinical albuminuria. Men with elevated ACR were more likely than those with normal ACR to smoke, use ACE inhibitors, and to have received conventional insulin therapy during the clinical trial. Men with elevated ACR were also more likely to have higher blood pressures, higher levels of glycosylated hemoglobin, and dyslipidemia.
The researchers report that IAF, but not SQF, was greater in men with elevated ACR compared to those with normal ACR (p = 0.048). Waist circumference (p = 0.048) and waist-to-hip ratio (p = 0.006) were greater in men with elevated ACR.
There was an association between elevated ACR and greater levels of each obesity measure, except SQF.
"Futures studies are needed to elucidate mechanisms underlying the IAF-albumin excretion link," the authors conclude.
