ACRIN is a privately held company which conductes a series of multicenter clinical trials, individually applied for and funded by the National Cancer Institute (NCI), that were the first to address imaging-related questions of importance to cancer diagnosis and care. In 1997, Dr. Robert Wittes, then the Director of the Division of Cancer Treatment and Evaluation Program (CTEP) at the NCI, convened two meetings which brought together imaging research stakeholders to explore the establishment of a research network to conduct a broad spectrum of medical imaging trials. A consensus emerged to endorse the endeavor given the growing importance of imaging to cancer care.